BaHSic Lab

BaHSic — Blood group Antigens, Hematopoiesis and Sickle cell disease

Hematopoiesis & Translational Research: blood cell biology, multi-omic approaches, and translational studies.

Contact (+33) 1 81 72 43 14 sara.bencheikh@inserm.fr

Location Hôpital Necker – Enfants Malades 149 rue de Sèvres 75015 Paris

Sandrine Laurance

Researcher

UMR_S1134 (BIGR) Inserm– BAHSic Lab

Sandrine Laurance, PhD is a Research Scientist leading an research program within the BaHSic team. Her work explores how bone marrow microenvironments regulate erythropoiesis under stress conditions, with a particular focus on sickle cell disease and aging-related anemia.

Research interests

Erythropoiesis and red blood cell biology
Hematopoietic stem and progenitor cells
Inflammatory anemia

Key expertise

Erythropoeisis
Flow cytometry
Proteomic and transcriptomic

Background

CRCN, Inserm UMR_S1134 (2021–Currently)
Post-doctorat, UMR_S1134 (2018–2021)
Post-doctoral Fellow, Lady Davis Institute, Université McGill (Canada) (2010–2018)
PhD – Université Paris Cité (2008) : Pharmacogenomic approach of hydroxyrurea treatment in Sicckle Cell Disease

Current projects

Her current projects combine cellular biology, proteomics, and functional models to investigate interactions between erythroid cells and their niche in a physiological but also in pathological context (sickle cell disease, inflammaging)

Personal interests

Running and Hiking
Cooking and discovering new cuisines
Traveling

🩸 Red blood cells 🔥 Inflammation 🧬 Blood group antigens 🧫 Sickle Cell Disease 🌱 Hematopoiesis 🛡️ Spleen Alloimmunization 🧬🔬 CRISPR-Cas9 • scRNA-seq • Proteomics • Microfluidics • Amnis • Rheology • ATAC-seq 🧫 Erythroid cell lines 🧪 Immunohematology

Contact

Hôpital Necker – Enfants Malades 149 rue de Sèvres 75015 Paris

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